Mode and dynamics of vanA-type vancomycin resistance dissemination in Dutch hospitals
نویسندگان
چکیده
منابع مشابه
VanA-type vancomycin-resistant Staphylococcus aureus.
Since 2002, nine methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) strains that are also resistant to vancomycin (VRSA) have been reported in the United States, including seven clinical isolates from Michigan. The strains harbor a plasmid-borne Tn1546 element following conjugation from a glycopeptide-resistant Enterococcus strain. In the second step, Tn1546 transposed to a residen...
متن کاملFitness cost of VanA-type vancomycin resistance in methicillin-resistant Staphylococcus aureus.
We have quantified the biological cost of VanA-type glycopeptide resistance due to the acquisition of the resistance operon by methicillin-resistant Staphylococcus aureus (MRSA) from Enterococcus sp. Exponential growths of recipient strain HIP11713, its transconjugant VRSA-1, VRSA-5, and VRSA-6 were compared in the absence or, except for HIP11713, in the presence of vancomycin. Induction of res...
متن کاملRevised manuscript AAC00346-09 VanA-type vancomycin-resistant Staphylococcus aureus
2 Staphylococcus aureus is one of the most common causes of hospital-and community-acquired infections and treatment of staphylococcal infections is complicated by the ability of this bacterial species to become resistant to antibiotics. Vancomycin is the drug of choice for therapy of infections due to methicillin-resistant S. aureus (MRSA) but increase in vancomycin use has led to the emergenc...
متن کاملClonal dissemination of vanA positive Enterococcus species in tertiary care hospitals in Karachi, Pakistan.
OBJECTIVE To perform molecular typing of vancomycin resistant Enterococcus spp. (VRE) strains endemic in various hospitals of Karachi, to characterize the mechanism of glycopeptide resistance and assess the genetic relatedness, for understanding its transmission locally. METHOD This was a cross sectional study conducted in the clinical and research laboratory of Aga Khan University Hospital (...
متن کاملDissemination of an Enterococcus Inc18-Like vanA plasmid associated with vancomycin-resistant Staphylococcus aureus.
Of the 9 vancomycin-resistant Staphylococcus aureus (VRSA) cases reported to date in the literature, 7 occurred in Michigan. In 5 of the 7 Michigan VRSA cases, an Inc18-like vanA plasmid was identified in the VRSA isolate and/or an associated vancomycin-resistant Enterococcus (VRE) isolate from the same patient. This plasmid may play a critical role in the emergence of VRSA. We studied the geog...
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ژورنال
عنوان ژورنال: Genome Medicine
سال: 2021
ISSN: 1756-994X
DOI: 10.1186/s13073-020-00825-3